Selection on noise constrains variation in a eukaryotic promoter

Nucleosomal promoter variation generates gene expression noise.

Gene product molecule numbers fluctuate over time and between cells, confounding deterministic expectations. The molecular origins of this noise of gene expression remain unknown. Recent EM analysis of single PHO5 gene molecules of yeast indicated that promoter molecules stochastically assume alternative nucleosome configurations at steady state, including the fully nucleosomal and nucleosome-f...

Transcriptional regulation constrains the organization of genes on eukaryotic chromosomes.

Genetic material in eukaryotes is tightly packaged in a hierarchical manner into multiple linear chromosomes within the nucleus. Although it is known that eukaryotic transcriptional regulation is complex and requires an intricate coordination of several molecular events both in space and time, whether the complexity of this process constrains genome organization is still unknown. Here, we prese...

Eukaryotic promoter recognition.

On ly recen tly h as it becom e common to determ in e eukaryotic gen om ic sequen ces large en ough to con tain several gen es. With th ese data com es a n ew problem for gen e fin din g program s: to partit ion a set of exon s correctly am on g several gen es. On e lin e of developm en t in eukaryot ic gen e iden tification begin s with codin g region iden tificat ion by statist ical m ean s a...

Genetic Variation in MMP-1 Promoter Region and

Selection constrains phenotypic evolution in a functionally important plant trait

A long-standing idea is that the macroevolutionary adaptive landscape – a ‘map’ of phenotype to fitness – constrains evolution because certain phenotypes are fit, while others are universally unfit. Such constraints should be evident in traits that, across many species, cluster around particular modal values, with few intermediates between modes. Here, I compile a new global database of 599 spe...